Role of Zingiber Officinale Rhizome Powder on Sex Hormones and Antioxidant Enzymes in The Male Rabbits

Abstract

The objective of this study was to investigate the effect of Zingiber Officinale rhizome powder administration ( 100 or 200 mg/kg) orally by gastric tube for 21days to male rabbits. Administration of Zingiber Officinale orally at dose 100 mg/kg caused a significant increase (p<0.05) on testosterone, FSH and LH concentration in the serum compared with control group. However, administration of Zingiber Officinale rhizome powder suspension orally at dose 200 mg/kg for 21 days, caused a non- significant increase in serum testosterone , FSH and a significant increase in serum LH compared with control group, The elevation of Testosterone, FSH and LH in G2 were 33.43% , 51.47% and 54.4%, and in G3 were 13.26%, 13.73 and 28.6% respectively when compared to control group. Administration of Zingiber Officinale rhizome powder suspension orally at dose 100 mg/kg or 200 mg/kg for twenty one days, caused a significant elevation in the levels of GST (67.36% and 74.99 % ) and CAT (174.36% and 183.39% ), respectively when compared to control group. A significant (P<0.05) increase in GST (67.36% and 74.99 % ) and CAT (174.36% and 183.39%), respectively was observed in Zingiber Officinale treated animals at dose 100 mg/kg or 200 mg/kg for 21 days compared with control group. In conclusion, the present study has demonstrated that, Zingiber Officinale rhizome powder suspension possess an androgenic and antioxidant activity in doses of 100 and 200 mg/kg respectively in adult male rabbits.