Effects of vitamin C on liver and kidney enzymes and some biochemical parameters against paracetamol induced hepato-nephrotoxicity in rats

Abstract

The current investigation aims to study the effects of VC against hepato-nephrotoxicity induced by PCM in rats. Forty male rats were divided into five groups with eight rats in each group. Group I (normal control): received distilled water orally, group II; received 500 mg/kg of VC, group III; received 500 mg/kg of PCM, group IV (protective group); received VC for 7 days, and then PCM for another 7 days, and group V treated with a combination of VC and PCM for 14 days. Results showed that a significant decline in percentage of change in body weights of treated rats with the PCM as compared to control rats while, animals that given VC with or before taken PCM showed a significant increase when compared with the PCM group. PCM caused significantly increased the liver and kidney enzymes (AST, ALP, ALT, TB, creatinine, urea, and uric acid) as well as cholesterol, and glucose levels when compared with normal rats. Whereas, animals in the protective group showed decreased liver and kidney enzymes and cholesterol, and glucose levels as compared to the PCM group. In conclusion, the results of this study demonstrate that VC was effective in reducing the hepato-nephrotoxicity caused by PCM in rats.