Antibiotics Sensitivity of Bacteria Associated with Urinary Tract Infection of Outpatients in Sirte City (Libya)

Abstract

Urinary tract infection (UTI) is one of the most common bacterial infections in humans and a major cause of morbidity among male and female. The pathogens traditionally associated with UTI and their antibiotic sensitivity patterns are changing from time to time and across different environment. Knowledge of the antibiotic resistance is an important factor for choosing an appropriate empirical antimicrobial treatment.

Study was designed to find the prevalence of UTI among patients complaining of UTI symptoms, to determine the causative organism (s) of UTI, and also to measure the antibiotic sensitivity of microbial agents isolated.

Urine samples collected were cultured on Agar media; strains isolated were identified using standard microbiological methods and tested for antimicrobial susceptibility via the disc diffusion method.

A total of 266 samples of outpatients, (156 female and 110 male). E. coli was the most common 130(48.9%) organism isolated, followed by Proteus mirabilis 61(22.9%), Klebsiella pneumonia 44(16.5%), Enterococcus faecalis 13(4.8%), S. aureus 11(4.1%), and Pseudomonas aeruginosa 7(2.6%). Imipenem, Augmentin and ciprofloxacin were found the most susceptible drug against isolated uropathogens, the resistance rate of isolates were more common in Clarithromycin, Ampicillin and Doxycycline.

Study notes increasing of antibiotics resistance among Uropathogenic isolates to most common drugs recommended. Therefore the antibiotics management’s plane should be developed locally in accordance with the susceptibility pattern of the uropathogens to avoid further resistance as well as morbidity of the patient