Abstract:
The aim of study was the evaluation of proficiency of rutin and stem cells on the kidney function changes induced by paracetamol in rats. 70 male rats were divided into two main studies. Primary study was used twenty young rats used as a source of bone marrow-derived MSCs. Secondary study were used fifty adult male rats which divided into 5 groups: Group (1) control group; group (2) were administrated of PCM (750 mg/kg b.w./every 72h) orally for 21 days, then left for 30 and 60 days without treatment, group (3) were administrated of PCM for 21 days then, treated with rutin (25mg/kg b.w/d) for 30 and 60 days, group (4) were administrated of PCM for 21 days then, the rats were injected by BM-MSCs (1.5x 106 cells in 0.5 PBS) in the tail vein for 30 and 60 days, and group (5) were administrated of PCM for 21 days then, the rats were injected by BM-MSCs in the tail vein, then treated with rutin for 30 and 60 days. PCM administration significantly increased the creatinine, urea levels with decreasing the albumin level when compared with normal rats at 30 and 60 days. While, rats treated with Q-3-R and MSCs showed a significant decrease in the creatinine, urea levels with increasing the albumin level when compared with PCM rats at 30 and 60 days. The rutin and BM-MSCs have the effects of the antioxidant activities, anti-inflammation and tissue regeneration on the PCM-induced kidney toxicity in rats.
