The role of High performance liquid chromatography to Identification of rat liver microsomes responsible for the in-vitro metabolite formation of Dipyrone

Abstract

Dipyrone is a non-steroidal anti-inflammatory drug (NSAID), commonly used in the past as a powerful painkiller and fever reducer. It is better known under the brand names Conmel®, Neo-Melubrina®, Magnopyrol®, Prodolina F®, Analgin®, and Novalgin®.

Because of the risk of serious adverse effects, its use is justified only in serious situations where no alternative is available or suitable.

السيرة الشخصية للمؤلف Salem Omran Ali Abdalla، Manara university, Pharmacy faculty, Department of Pharmacology Private Univerisity, Latakia, Syria Manara university, Pharmacy faculty, Department of Pharmacology

Private Univerisity, Latakia, Syria

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presents the contributor to the main of metabolism of metamizole in rat liver