Evaluation Of Hepatoprotective Activity Of Aqueous Extract Of Indian Costus Roots On Paracetamol Induced Hepatotoxicity In Albino Mice

Abstract

القسط الهندي من النباتات التي تستخدم كثيرا في الطب الشعبي في علاج الكثير من الامراض مثل السرطانات وامراض الدم والامراض التنفسيه وقد كان الهدف من هذا البحث هو دراسة تاثير مستخلص جذور القسط الهندي علي السميه الكبديه المستحدثه في الفأران بواسطة عقار الباراسيتامول واعتمدت الطريقه علي تقسيم الفأران لخمس مجموعات هي ا ,ب ,ج ,د ,ه حيث كانت المجموعه أ هي المجموعه الضابطه وحقنت المجموعه ب بالجرعه العلاجيه لعقار الباراسيتامول وهي 14 ميكروجرام لكل كيلو جرام من وزن الجسم بينما حقنت المجموعه ج بالجرعه السميه وهي 85 ميكروجرام لكل كيلو جرام من وزن الجسم داخل الغشاء البروتيني لمدة اربع ايام وجرعت المجموعتين د و ه بالمستخلص المائي لجذور القسط الهندي عن طريق الفم لمدة اربع ايام ثم حقنت في اليوم الخامس بعقار الباراسيتامول بالجرعات العلاجيه للمجموعه د والجرعه السميه للمجموعه ه لمدة اربع ايام ثم ذبحت الفأران وتم ارسال عينات الدم الي المختبرلفحص انزيمات الكبد وهي انزيم ناقلة الالانين وانزيم ناقلة الاسبرتات وانزيم الفوسفاتاز القلوي واخذت عينات من الكبد لاجراء الفحص النسيجي وتبين من النتائج ان المستخلص المائي لجذور القسط الهندي سبب في انخفاض الاثار السميه علي الكبد التي سببها عقار الباراسيتامول في المجموعات د و ه مقارنتاً بالمجموعتين ب و ج التي لم تجرع بمستخلص القسط الهندي مايشير الي ان القسط الهندي يمكن ان يستخدم كعلاج للسميه الكبديه الناتجه عن تعاطي الادويه ويحتاج لاجراء المزيد من الابحاث.

السير الشخصية للمؤلفين Kaula. A. Saad، National Center of Diseases Control - Tripoli- Libya. National Center of Diseases Control - Tripoli- Libya.

Nagia. A. Abdalsalam، Department of Clinical Diagnostic- Faculty of VetrinaryMedicine-Omar Al-mukhtar University-Albeida-libya Department of Clinical Diagnostic- Faculty of VetrinaryMedicine-Omar Al-mukhtar University-Albeida-libya

Intisar.O. Abdalla، Department of Pathology- Faculty of VetrinaryMedicine-Omar Al-mukhtar University-Albeida-libya Department of Pathology- Faculty of VetrinaryMedicine-Omar Al-mukhtar University-Albeida-libya

Hanan. A. Alkailani، Department of Pharmacology-Faculty of Vetrinary Medicine-Omar Al-mukhtar University-Albeida-libya. Department of Pharmacology-Faculty of Vetrinary Medicine-Omar Al-mukhtar University-Albeida-libya.

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