Evaluation the Role of Melatonin and Cortisol in Thalassemia Patients with Sickle Cell Anemia

Abstract

The study included the estimation of some biochemical variables in thalassemia patients with sickle cell anemia of both sexes, comparing them with a group of healthy control. The study included (43) cases collected from Al-Hadba Hospital in Mosul city and was divided into two groups: the first group consisted of 20 patients, and the second group included 23 healthy cases. Levels of melatonin and cortisol were analyzed, in addition to other blood indicators such as hemoglobin (Hb), white blood cell count (WBC), and platelets (PLT). The results showed that thalassemia patients with sickle cell anemia suffered from a significant decrease in hemoglobin levels compared to healthy individuals, along with varying increases in white blood cell and platelet counts. Moreover, melatonin concentration decreased, and cortisol increased significantly compared to the control group, with clear differences in some biomarkers between the two studied age categories. Higher levels of both melatonin and cortisol were recorded in females compared to males.